[HTML][HTML] Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
RC Muise-Helmericks, HL Grimes, A Bellacosa… - Journal of Biological …, 1998 - ASBMB
Cyclin D expression is regulated by growth factors and is necessary for the induction of
mitogenesis. Herbimycin A, a drug that binds to Hsp90, induces the destruction of tyrosine
kinases and causes the down-regulation of cyclin D and an Rb-dependent growth arrest in
the G 1 phase of the cell cycle. We find that the induction of D-cyclin expression by serum
and its repression by herbimycin A are regulated at the level of mRNA translation. Induction
of cyclin D by serum occurs prior to the induction of its mRNA and does not require …
mitogenesis. Herbimycin A, a drug that binds to Hsp90, induces the destruction of tyrosine
kinases and causes the down-regulation of cyclin D and an Rb-dependent growth arrest in
the G 1 phase of the cell cycle. We find that the induction of D-cyclin expression by serum
and its repression by herbimycin A are regulated at the level of mRNA translation. Induction
of cyclin D by serum occurs prior to the induction of its mRNA and does not require …