Decoding ARE-mediated decay: is microRNA part of the equation?
C Von Roretz, IE Gallouzi - The Journal of cell biology, 2008 - rupress.org
The Journal of cell biology, 2008•rupress.org
Messenger ribonucleic acids (mRNAs) containing adenine/uridine-rich elements (AREs) in
their 3′ untranslated region are particularly labile, allowing for the regulation of expression
for growth factors, oncoproteins, and cytokines. The regulators, effectors, and location of
ARE-mediated decay (AMD) have been investigated by many groups in recent years, and
several links have been found between AMD and microRNA-mediated decay. We highlight
these similarities, along with recent advances in the field of AMD, and also mention how …
their 3′ untranslated region are particularly labile, allowing for the regulation of expression
for growth factors, oncoproteins, and cytokines. The regulators, effectors, and location of
ARE-mediated decay (AMD) have been investigated by many groups in recent years, and
several links have been found between AMD and microRNA-mediated decay. We highlight
these similarities, along with recent advances in the field of AMD, and also mention how …
Messenger ribonucleic acids (mRNAs) containing adenine/uridine-rich elements (AREs) in their 3′ untranslated region are particularly labile, allowing for the regulation of expression for growth factors, oncoproteins, and cytokines. The regulators, effectors, and location of ARE-mediated decay (AMD) have been investigated by many groups in recent years, and several links have been found between AMD and microRNA-mediated decay. We highlight these similarities, along with recent advances in the field of AMD, and also mention how there is still much left unknown surrounding this specialized mode of mRNA decay.
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