Heparanase regulates esophageal keratinocyte differentiation through nuclear translocation and heparan sulfate cleavage
M Kobayashi, Y Naomoto, T Nobuhisa, T Okawa… - Differentiation, 2006 - Elsevier
Heparanase is an endo-β-glucuronidase that specifically cleaves heparan sulfate (HS)
chains. Heparanase is involved in the process of metastasis and angiogenesis through the
degradation of HS chains of the extracellular matrix and cell surface. Recently, we
demonstrated that heparanase was localized in the cell nucleus of normal esophageal
epithelium and esophageal cancer, and that its expression was correlated with cell
differentiation. However, the nuclear function of heparanase remains unknown. To elucidate …
chains. Heparanase is involved in the process of metastasis and angiogenesis through the
degradation of HS chains of the extracellular matrix and cell surface. Recently, we
demonstrated that heparanase was localized in the cell nucleus of normal esophageal
epithelium and esophageal cancer, and that its expression was correlated with cell
differentiation. However, the nuclear function of heparanase remains unknown. To elucidate …
