The proper detection and repair of DNA damage is essential to the maintenance of genomic
stability. The genome is particularly vulnerable during DNA replication, when endogenous
and exogenous events can hinder replication fork progression. Stalled replication forks can
fold into deleterious conformations and are also unstable structures that are prone to
collapse or break. These events can lead to inappropriate processing of the DNA, ultimately
resulting in genomic instability, chromosomal alterations and cancer. To cope with stalled …