Chromosomal translocations involving the mixed lineage leukemia (MLL) gene are often
observed in acute leukemias of both myeloid and lymphocytic origin. Expression of MLL
fusion proteins is known to induce malignant transformation of normal blood progenitors;
however, molecular mechanisms of this process are still poorly understood. In this study we
investigated the effect of several frequently detected MLL fusion proteins on p53
transcriptional activity. Our data show that MLL-AF9, MLL-AF10, MLL-ENL, and MLL-ELL …