The bright side of the glial scar in CNS repair
A Rolls, R Shechter, M Schwartz - Nature Reviews Neuroscience, 2009 - nature.com
A Rolls, R Shechter, M Schwartz
Nature Reviews Neuroscience, 2009•nature.comFollowing CNS injury, in an apparently counterintuitive response, scar tissue formation
inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar-
modulating treatments have become a leading therapeutic goal in the field of spinal cord
injury. However, increasing evidence suggests a beneficial role for this scar tissue as part of
the endogenous local immune regulation and repair process. How can these opposing
effects be reconciled? Perhaps it is all a matter of timing.
inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar-
modulating treatments have become a leading therapeutic goal in the field of spinal cord
injury. However, increasing evidence suggests a beneficial role for this scar tissue as part of
the endogenous local immune regulation and repair process. How can these opposing
effects be reconciled? Perhaps it is all a matter of timing.
Abstract
Following CNS injury, in an apparently counterintuitive response, scar tissue formation inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar-modulating treatments have become a leading therapeutic goal in the field of spinal cord injury. However, increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process. How can these opposing effects be reconciled? Perhaps it is all a matter of timing.
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